The following points highlight the eleven major physiological effects of ethylene. The Agency for Toxic Substances & Disease Registry has some guidelines for treating ethylene oxide exposure. October 1, 2020 By Nancy Crotti. 2005; 23(1):6-8 (ISSN: 1001-9391) Sun LL; Zhang FQ . Agency for Toxic Substances and Disease Registry (ATSDR), (December 1990). An Evaluation of Possible Effects on Health Following Exposure To Ethylene Oxide. Ethylene Oxide. Alkylation of DNA and hemoglobin in the mouse following exposure to propene and propylene oxide. Ethylenoxid [MAK Value Documentation in German language, 2002]. Formation of Adventitious Roots and Root Hairs 5. IARC Classification: Carcinogenic to humans (Group 1). Humans exposed to polychlorinated biphenyls (PCBs) and polychlorinated dibenzofurans (PCDFs) exhibit increased SCE frequencies in lymphocytes when incubated with α-naphthoflavone: Involvement of metabolic activation by P-450 isozymes. Draft Toxicological Profile for Chlorine Dioxide and Chlorite. 1. May cause an allergic skin reaction in some people. The measured maximum concentration of ethylene oxide in the sterilizer room was 36 ppm (within standards set by the Occupational Safety and Health Administration). It is also an irritant to skin and the respiratory tract, and inhaling the vapors may cause the lungs to fill with fluid several hours after exposure. 1.5 What levels of exposure have resulted in harmful health effects? 1.2 How might I be exposed to ethylene oxide? Ethylene oxide has besides its toxic reaction a mutagenic effect upon human fibroblasts. Ethylene oxide is a known mutagen as indicated by short-term testing in vitro and in vivo. SUMMARY AND EVALUATION 2.1 Human Exposure to Ethylene Oxide Human exposure occurs mainly through inhalation in sterilization facilities and in production plants. Ethylene oxide is a direct-acting alkylating agent that has been used as an industrial intermediate and as a Neurotoxicological evaluation of hospital sterilizer workers exposed to ethylene oxide. 888-232-6348 (TTY) Toxicological Profile for Ethylene Oxide. Ethylene Oxide 75-21-8 Hazard Summary The major use for ethylene oxide is as a chemical intermediate in industry. Effect of concentration—time parameters on sister-chromatid exchanges induced in rabbit lymphocytes by ethylene oxide inhalation. Ethylene Oxide (ETO) as a Major Cause of Anaphylactoid Reactions in Dialysis (A review). 1, 3-butadiene, ethylene oxide and vinyl halides (vinyl fluoride, vinyl chloride and vinyl bromide). For this reason, some items on this page will be unavailable. EPA has concluded that ethylene oxide is carcinogenic to humans by the inhalation route of exposure. It dissolves easily in water.Ethylene oxide is a man-made chemical that is used primarily to make ethylene glycol (a chemical used to make antifreeze and polyester). Ullmann's Encyclopedia of Industrial Chemistry. For more information about this message, please visit this page: Agency for Toxic Substances & Disease Registry. A) Early signs and symptoms of exposure to ethylene oxide (ETO) may include eye, nose, and throat irritation and noticing a sweet or peculiar taste in the mouth. Occupational exposure can occur during ethylene oxide gas sterilization of materials for hospital and other use. Incidental exposure may also increase sister chromatid exchange. Toxicological Perspectives on Biologically Based Cancer Risk Assessment. Note: Javascript is disabled or is not supported by your browser. Liteplo and M.E. Protective effect of low doses in mutagenesis with ethylene oxide in E. coli. It dissolves easily in water.Ethylene oxide is a man-made chemical that is used primarily to make ethylene glycol (a chemical used to make antifreeze and polyester). * This chemical is on the Special Health Hazard Substance List because it is FLAMMABLE and REACTIVE. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans; World Health Organization. ATSDR can also tell you the location of occupational and environmental health clinics. Because ethylene oxide destroys DNA, it can increase the risk of certain cancers. ETHYLENE OXIDE: HAZARD CHARACTERIZATION AND EXPOSURE–RESPONSE ANALYSIS. The incidence of this disease in the exposed females increased linearly with dose. 0.2.1 SUMMARY OF EXPOSURE. Tubes with residues of 200 to 600 ppm ethylene oxide brought about a consistent rise of the SCE ratio in the sense of a dose-response relationship. May harm the nervous system. Janice W. Yager, Effect of concentration—time parameters on sister-chromatid exchanges induced in rabbit lymphocytes by ethylene oxide inhalation, Mutation Research/Environmental Mutagenesis and Related Subjects, 10.1016/0165-1161(87)90076-8, 182, 6, (343-352), (1987). OBJECTIVE: To study the hazards of demulsifier production process. Enter your email address below and we will send you your username, If the address matches an existing account you will receive an email with instructions to retrieve your username, By continuing to browse this site, you agree to its use of cookies as described in our, I have read and accept the Wiley Online Library Terms and Conditions of Use. 1995). The physiological effects are: 1. Risk of fire and explosion as a result of decomposition when heated. ETHYLENE OXIDE Please note that the layout and pagination of this pdf file are not identical to those of the printed CICAD First draft prepared by R.G. 1.7 What recommendations has the federal government made to protect human health? 4 PART 1, p. 544-546. Studies show that long-term exposure to ethylene oxide can cause cancers of the white blood cells in humans, including non-Hodgkin lymphoma, myeloma and lymphocytic leukemia, according to the EPA. Ethylene oxide gas may produce immediate local irritation of the skin, eyes, and upper respiratory tract. The International Agency for Research on Cancer (IARC) and the United States Environmental Protection Agency (USEPA) classified EtO as a known human carcinogen. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. "Teratogenesis, Carcinogenesis, and Mutagenesis". They consist of … The EPA and the federal Department of Health and Human Services both consider EtO a human carcinogen. Among male Fischer 344 rats in the same experiment EtO induced peritoneal mesothelioma which originated in the testicular mesothelium. Source: ... Because side effects of acute ethylene oxide exposure can occur up to 72 hours after exposure, anyone who suspects exposure should go to a medical facility for evaluation. Email: Contact CDC-INFO. Ethylene oxide causes acute poisoning, accompanied by the following symptoms: slight heartbeat, muscle twitching, flushing, headache, diminished hearing, acidosis, vomiting, dizziness, transient loss of consciousness and a sweet taste in the mouth. Sister chromatid exchange frequency in workers exposed to high levels of ethylene oxide, in a hospital sterilization service. Ethylene oxide is an alkylating agent; it has irritating, sensitizing and narcotic effects. Biological and chemical monitoring of occupational exposure to ethylene oxide. The major effects seen in workers exposed to ethylene oxide at low levels for several months or years are irritation of the eyes, skin, and mucous membranes and problems in the functioning of the brain and nerves. Sister-chromatid exchanges and chromosome aberrations in lymphocytes from monkeys exposed to ethylene oxide and propylene oxide by inhalation. Use of Biochemical and Molecular Biomarkers for Cancer Risk Assessment in Humans. Headache, nausea, and vomiting have been reported. Peripheral nerve damage of impairment incidence rate was 40.4%, significantly higher than that in … * Definitions are provided on page 5. Garry VF, Hozier J, Jacobs D, Wade RL, Gray DG. Sister chromatid exchanges were studied in lymphocytes cultured from exposed individuals as well as comparable controls. Biological monitoring in surveillance of exposure to genotoxicants. Learn about our remote access options, Section of Health Risk Assessment, Minnesota Department of Health, Minneapolis, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Department of Surgery, Hennepin County Hospital, Minneapolis. Within this group of symptomatic and asymptomatic individuals, chronic and incidental exposure was documented by clinical history. Adverse health effects of ethylene oxide and occupational exposure limits. Ethylene oxide: An overview of toxicologic and epidemiologic research. Vincent F. Garry, John Hozier, Donald Jacobs, Richard L. Wade ... Incidental exposure may also increase sister chromatid exchange. Applications of Genetic Toxicology to Human and Environmental Monitoring. Ethylene oxide is a flammable gas with a somewhat sweet odor. NO open flames, NO sparks and NO smoking. Ethylene oxide is usually stored as a pressurized or refrigerated liquid. Ethylene oxide is a known mutagen as indicated by short-term testing in vitro and in vivo. Chromosome analysis of lymphocytes from workers at an ethylene oxide plant. 1.4 How can ethylene oxide affect my health? International Archives of Occupational and Environmental Health. Chronic exposure to ethylene oxide is also mutagenic. Leaf … Mutation Research/Reviews in Genetic Toxicology. OBJECTIVE: To study the hazards of demulsifier production process. Although humans and animals may differ in their susceptibility to specific chemical compounds, any substance that produces cancer in experimental animals should a… The dangerous side effects and human carcinogen health risks involved in the use of Ethylene Oxide have mostly been hidden from public view. Sister Chromatid Exchange Analysis in Lymphocytes. Mortality among Workers Exposed to Ethylene Oxide. Working off-campus? Gas/air mixtures are explosive. There also is some evidence linking ethylene oxide exposure to reproductive effects. Ethylene oxide: Evidence of human chromosomal effects. It also increases the risk of breast cancer in women. At high concentrations, it may cause an immediate or delayed accumulation of fluid in the lungs. Ethylene oxide (EO) is an important industrial chemical that is classified as a known human carcinogen (IARC, Group 1). ethylene glycol provided in the expert panel report, the public comments, and additional scientific information available since the expert panel meeting. Cytogenetic damage in workers exposed to ethylene oxide. In animals, chronic exposure causes leukemia and intra-abdominal cancer, and there is some evidence that it increases the risk of leukemia in human workers. Ethylenoxid [MAK Value Documentation in German language, 1984]. The NTP brief is intended to provide clear, balanced, scientifically sound information on the potential for ethylene glycol exposures to result in adverse effects on human 1.6 Is there a medical test to determine whether I have been exposed to ethylene oxide? Ethylene oxide is known to be a human carcinogen based on evidence from studies in humans and experimental animals and from supporting mechanistic data. Ethylene oxide. It is a colorless, poisonous gas that attacks the cellular proteins and nucleic acids of microorganisms. 1.3 How can ethylene oxide enter and leave my body? Occupational exposure can occur during ethylene oxide gas sterilization of materials for hospital and other use. Effects of Long-Term (Chronic) Exposure: Can cause dry, red, cracked skin (dermatitis) following skin contact. Genetic Toxicology of Some Known or Suspected Human Carcinogens. Author information: (1)Binzhou Center for Disease Control and Prevention, Binzhou 256618, China. To determine the minimum sterilization time required and the effect of ethylene oxide on bone's osteoinductive capacity and chemical structure, samples were exposed to ethylene oxide for different times (5-240 min). Fruit Ripening 2. Cytogenetic, immunological, and haematological effects in workers in an ethylene oxide manufacturing plant.. Human Cytogenetic Monitoring: Occupational Exposure to Ethylene Oxide. The acute (short-term) effects of ethylene oxide in humans consist mainly of central nervous system (CNS) depression and irritation of the eyes and mucous membranes. Ethylene oxide is a known mutagen as indicated by short‐term testing in vitro and in vivo. It is a clear, colorless liquid below its boiling point of 10 degrees C. It is explosive when heated or in the presence of alkali metal hydroxides and catalytic surfaces. A Review and Evaluation of Human Genetic Bioassay Data for Some Known or Suspected Human Carcinogens. A study of sister chromatid exchange and somatic cell mutation in hospital workers exposed to ethylene oxide.. Evaluation in Man and Animals of Tests for the Detection of Population Exposures to Genotoxic Chemicals. recognizing, evaluating, and treating illnesses resulting from exposure to hazardous substances. Use the link below to share a full-text version of this article with your friends and colleagues. Detection of sister chromatid exchanges induced by volatile genotoxicants. Review of the mutagenicity of ethylene oxide. Preparation for Human Study of Pesticide Applicators: Sister Chromatid Exchanges and Chromosome Aberrations in Cultured Human Lymphocytes Exposed to Selected Fumigants. Sister chromatid exchanges induced in rabbit lymphocytes by ethylene oxide after inhalation exposure. Ethylene oxide: evidence of human chromosomal effects. Ethylene oxide is a flammable gas with a somewhat sweet odor. 74, no. Ethylene modulates calcium regulation and other functions in animal cells. Ethylene oxide (EtO) is produced in large volumes and is primarily used as an intermediate in the production of several industrial chemicals, the most notable of which is ethylene glycol. Mutation Research/Genetic Toxicology and Environmental Mutagenesis. Occupational exposure can occur during ethylene oxide gas sterilization of materials for hospital and other use. Biomonitoring of exposure to potential mutagens and carcinogens in industrial populations. Download Citation | [Effects of ethylene oxide and propylene oxide on human health] | To study the hazards of demulsifier production process. Chronic (long-term) exposure to EtO in humans can cause irritation of the eyes, skin, nose, throat, and lungs, and damage to … Chromosomal aberrations and sister-chromatid exchanges in tool and die workers. Four chronically exposed persons who reported upper respiratory and neurologic symptoms were studied in some detail. The Interaction between Epidemiology and Animal Studies in Industrial Toxicology. The acute (short-term) effects of ethylene oxide in humans consist mainly of central nervous system (CNS) depression and irritation of the eyes and mucous membranes. 2005; 23(1):6-8 (ISSN: 1001-9391) Sun LL; Zhang FQ. Mutagenicity testing in environmental toxicology. REASON FOR CITATION * Ethylene is on the Hazardous Substance List because it is cited by ACGIH, DOT, DEP, NFPA and EPA. Human diploid VH-10 fibroblasts were pre-exposed to γ-rays and then treated with ethylene oxide (EtO). In 2016, the EPA classified ethylene oxide as cancerous to humans. Individual Susceptibility to Genotoxic Agents in the Human Population. Harmful effects of ethylene oxide on humans, stringent government regulation guiding the application of ethylene oxide on polyester fiber and TEP resin and rise in health issues are the significant factors expected to obstruct the growth of global ethylene oxide market during the forecast period. [Article in Chinese] Sun LL(1), Zhang FQ. Genetic Bioassay Data on Some Known or Suspected Human Carcinogens. 3. Tox Town, from the National Library of Medicine, provides consumer-level information on toxic chemicals in everyday places and situations, potential health effects, and ways to reduce the risk. Detection of Effects of Mutagens in Human Populations. Effects from short-term exposure to high levels of ethylene oxide in humans can include central nervous system depression and irritation of the eyes and mucous membranes. Triple Response 4. Inhibition of Root Growth 6. To study the problem in a hospital sterilization facility where occupational exposure was suspected, epidemiologic, analytic, and bioassay tools were employed. Ethylene oxide caused dose-related increases in the frequency of he-moglobin adducts in exposed humans and rodents. Exposure may occur through industrial emissions, tobacco smoke, and the use of products sterilized with ethylene oxide, such as certain medical products or cosmetics. Children experiencing the effects of chronic exposure to Ethylene Oxide can be significantly more severe than the damage caused to adults due to its human carcinogen properties. The MAK‐Collection for Occupational Health and Safety. Ethylene oxide causes acute poisoning, accompanied by a variety of symptoms. CDC: Ethylene oxide may have more health effects than cancer. Ethylene oxide has caused statistically significant increases in mononuclear cell leukemia in female Fischer 344 rats. Assessing the Feasibility of Retrospective Cohort Studies. Ethylene oxide is a known mutagen as indicated by short‐term testing in vitro and in vivo. Ethylene oxide (EtO) is a highly reactive chemical used as a sterilizing agent and a feedstock for producing other chemicals. and you may need to create a new Wiley Online Library account. Garry VF, Hozier J, Jacobs D, Wade RL, Gray DG. Plumular Hook Formation 3. The Rationale and Methodology for Quantifying Sister Chromatid Exchange in Humans. This group showed significantly increased sister chromatid exchange at three weeks and again at eight weeks after the last known exposure. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. ToxFAQs™ for Ethylene Oxide. It is also used as a fumigant in certain agricultural products and as a sterilant for medical equipment and supplies. ET has not produced evidence of cancer in laboratory animals and is “not classifiable as to its carcinogenicity to humans” (IARC, Group 3). The genotoxic effects of three important aliphatic epoxides, ethylene oxide (EtO), propylene oxide (PO) and the halogenated epoxide epichlorohydrin (ECH), are described. Authors. It is believed that ethylene is not produced in species outside the plant kingdom and some microorganisms. Ethylene oxide is a known mutagen as indicated by short‐term testing in vitro and in vivo. In severe cases, symptoms may include muscle weakness, loss of feeling or prickly sensation in the hands, feet, arms or legs, clumsiness and paralysis. HOW TO DETERMINE IF YOU ARE BEING EXPOSED … [Effects of ethylene oxide and propylene oxide on human health]. Carcinogenic and toxicologic effects of inhaled ethylene oxide and propylene oxide in F344 rats. Chronic (long-term) exposure to ethylene oxide in humans can cause et al., «IgE against ethylene oxide-altered human serum albumin in patients who have had acute dialysis reactions.» Journal of Allergy and Clinical Immunology. The Use of Human Cells for the Evaluation of Risk from Physical and Chemical Agents. Closed system, ventilation, … Vol. Residues in medical equipment that has been sterilized with ethylene oxide and insufficiently aerated can migrate into tissues and blood, producing primarily local effects. Ethylene Oxide 75-21-8 Hazard Summary The major use for ethylene oxide is as a chemical intermediate in industry. Ethylene oxide (EO), an industrial intermediate and gaseous sterilant for medical devices, is carcinogenic to humans, which warrants minimization of exposure in the workplaces. profile for ethylene oxide, Agency for Toxic Substances and Disease Registry. Learn about ethylene oxide, which can raise your risk of lymphoma and leukemia. Mutation Research/Environmental Mutagenesis and Related Subjects. Statistical model for prediction of retrospective exposure to ethylene oxide in an occupational mortality study. Effect of sample holding, cryopreservation, and storage on the human lymphocyte cytogenetic test. At room temperature and pressure, it rapidly evaporates, potentially causing frostbite in cases of skin exposure. * Ethylene Oxide sterilization Over 20,000 healthcare facilities worldwide use Ethylene oxide sterilizers to process sensitive instruments which cannot be adequately sterilized by other methods. Quantitative estimation of the genetic risk associated with the induction of heritable translocations at low‐dose exposure: Ethylene oxide as an example. The incidence of Achilles's tendon reflection, knee jerk slacking up, chronic pharyngitis, coryza, acne, hair lose and pneumonia were significantly higher in study group than that in control group (P <0.01). This is why I would NEVER buy flowers from a Petrol station as their life would be at least reduced by two thirds due to the ethylene from car exhausts. Symptoms of overexposure include headache and dizziness, progressing with increasing exposure to convulsions, seizure and coma. It was found that G 1 arrest is induced by these epoxides 6–18 h after the treatment at doses above 5, 3, and 0.5 mMh for EtO, PO, and ECH, respectively. An Integrated Approach to Human Monitoring. Journal of Toxicology: Clinical Toxicology. In some persons, ethylene oxide exposure may result in allergic sensitization, and future exposure may cause hives or a life-threatening allergic reaction. To study the problem in a hospital sterilization facility where occupational exposure was suspected, epidemiologic, analytic, and bioassay tools were employed. Another group of eight persons with fewer complaints studied as late as the ninth week showed significantly increased exchanges. used ethylene oxide as a sterilant (Norman et al. Chromosome aberrations in individuals occupationally exposed to ethylene oxide, and in a large control population. These clinics specialize in Many other chemical substances have mutagenic potencies also. Even minimal exposure to highly toxic Ethylene Oxide gas can create an increased risk of adverse health effects, including blurred vision, difficulty with breathing, breast cancer, and nervous system conditions. Ethylene oxide: Evidence of human chromosomal effects. Ethylene oxide is also used as a fumigant and sterilant for microbial organisms in a variety of applications. ETHYLENE OXIDE Please note that the layout and pagination of this pdf file are not identical to ... the potential effects of chemicals upon human health and/or the environment. The International Agency for Research on Cancer has determined that ethylene oxide is carcinogenic to humans. (APF = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted canister providing protection against ethylene oxide*; or Any self-contained breathing apparatus with a full facepiece; or Any supplied-air respirator with a full facepiece. All persons whose work activities involved some aspect of the sterilization process were considered exposed to the gas. 2. Ethylene Oxide and Some Factors Affecting the Mutagen Sensitivity of Sister Chromatid Exchange in Humans. Ethylene oxide [MAK Value Documentation, 1993]. Toxicological Profile for Ethylene Oxide. Sister chromatid exchanges and DNA repair capability in sanitary workers exposed to ethylene oxide: Evaluation of the dose‐effect relationship. An Overview of Approaches for Genetic Monitoring of Humans. Archives of Environmental Health: An International Journal. SCE increases after an accidental acute inhalation exposure to EtO and recovery to normal after 2 years. Occupational hazards to health care workers: Diverse, ill-defined, and not fully appreciated. OBJECTIVE: To study the hazards of demulsifier production process. Studies on Mechanisms of Carcinogenesis Ethylene oxide is a direct-acting alkylating agent that forms adducts with biological macromolecules, including hemoglobin and DNA. In the reverse experiment, the cells were pretreated with EtO and then exposed to γ-rays. Chronic ethylene oxide exposure may increase the risk of cataracts in humans. Its reproductive effects on humans have not been well studied, but it is considered probable that ethylene oxide exposure has similar effects on human reproduction. Specific attention was paid to smoking as a potential source of exposure. Ethylene oxide (EtO), propylene oxide (PO), and epichlorohydrin (ECH) strongly influenced the G 1 /S progression in human diploid fibroblasts, VH-10. Download Citation | [Effects of ethylene oxide and propylene oxide on human health] | To study the hazards of demulsifier production process. The International Agency for Research on Cancer classifies ethylene oxide into group 1, meaning it is a proven carcinogen. 1 Effects of Nitinol Surface Treatments and Ethylene Oxide Sterilization on Human Lymphocyte Proliferation. Effects On Humans and Animals. Some of the BAD effects of Ethylene are to cause vegetables to go yellow, bud damage in dormant nursery stock, drop off of leaves in ornamentals and rapid death of most cut flowers. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. Volume 97. Demineralized human bone used as an autologous bone graft substitute is ethylene oxide sterilized, which is reported to reduce the bone's osteoinductive potential. Children experiencing the effects of chronic exposure to Ethylene Oxide can be significantly more severe than the damage caused to adults due to its human carcinogen properties. It is also used as a fumigant in certain agricultural products and as a sterilant for medical equipment and supplies. It is also a metabolite of ethylene (ET), a compound that is ubiquitous in the environment and is the most used petrochemical. If you do not receive an email within 10 minutes, your email address may not be registered, Sister-chromatid exchanges in association with occupational exposure to ethylene oxide. Ethylene oxide is the simplest epoxide. Perspectives in Basic and Applied Toxicology. It dissolves easily in water. Two different dose rates of γ-rays were used: a low dose rate (LDR, 0.66 Gy/min) and a high dose rate (HDR, 10 Gy/min). Historically, ethylene glycol has been commercially produced on a large-scale ba-sis by hydration of ethylene oxide. Ethylene oxide (EtO) is produced in large volumes and is primarily used as an intermediate in the production of several industrial chemicals, the most notable of which is ethylene glycol. Grammer, L.C. Ethylene Effects On Humans. [Effects of ethylene oxide and propylene oxide on human health]. Ethylene oxide (EO) is widely used in the health care industry as a gas sterilant for medical products that cannot withstand the high temperature and humidity associated with conventional steam sterilization. Inhalation of ethylene oxide can produce CNS depression, and in extreme cases, respiratory distress and coma. Objective: The influence of the polymorphic human glutathione-S-transferase (GST) T1 and M1 genotypes (classified as "conjugators" and "nonconjugators") on the biological effects of nonoccupational ethylene oxide exposure as reflected by the formation of globin N2-hydroxyethylvaline adducts was investigated. Ethylene oxide is toxic by inhalation. 1 Effects of Nitinol Surface Treatments and Ethylene Oxide Sterilization on Human Lymphocyte Proliferation. Short-Term Bioassays in the Analysis of Complex Environmental Mixtures IV. Number of times cited according to CrossRef: Biological Monitoring in Surveillance of Exposure to Genotoxicants. Ethylene oxide is a highly reactive, flammable gas with a somewhat sweet odor. Cytogenetic Monitoring of Human Populations. Ethylene Oxide, Mustard Gas and other organics, and to accelerate the ripening of fruits. Chronic (long-term) exposure to ethylene oxide in humans can cause However, these epoxides did not affect substantially the G 2 /M progression. Central nervous system effects are frequently associated with human exposure to ethylene oxide in occupational settings. The DHHS has determined that ethylene oxide is known to be a human carcinogen (NTP 2011). Sister-chromatid exchange induction in peripheral blood lymphocytes of rats exposed to ethylene oxide by inhalation. Biologic monitoring of exposure to chemical mutagens in the occupational environment. Learn more. Non-Human Toxicity Values; Ecotoxicity Values; Soil Adsorption / Mobility; Volatilization; Ethylene Oxide CAS RN: 75-21-8 Health Effects. The NTP brief is intended to provide clear, balanced, scientifically sound information on the potential for ethylene glycol exposures to result in adverse effects on human Unexpected decrease in cytogenetic biomarkers frequencies observed after increased exposure to organophosphorus pesticides in a production plant. Please check your email for instructions on resetting your password. May 28, 2018 - Ethylene oxide may have negative effects on humans and the environment ☆ READ MORE ☆ Scan your favorite products for toxic ingredients. 0.2.1.1 ACUTE EXPOSURE. Journal of Environmental Science and Health, Part C. Induction and persistence of micronuclei, sister-chromatid exchanges and chromosomal aberrations in splenocytes and bone-marrow cells of rats exposed to ethylene oxide. Demineralized human bone used as an autologous bone graft substitute is ethylene oxide sterilized, which is reported to reduce the bone's osteoinductive potential. [Effects of ethylene oxide and propylene oxide on human health]. One fundamental question is whether plant ethylene production has a xenohormetic effect (cross-species hormonal effect) on animals that consume them. Ethylene oxide: evidence of human chromosomal effects. Profile for ethylene oxide, Toxicological IARC monographs on the evaluation of carcinogenic risks to humans. Currently, it is also produced by the oxidation of ethylene in the presence of acetic acid to form ethylene diacetate, which is then hydrolysed to the … Risk Assessment and Oncodynamics of Ethylene Oxide as Related to Occupational Exposure. ethylene glycol provided in the expert panel report, the public comments, and additional scientific information available since the expert panel meeting. Chromosomal aberrations and micronuclei in lymphocytes in relation to alkylation of hemoglobin in workers exposed to ethylene oxide and propylene oxide.